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Research in Review

Reviewing the Latest Research on Value-Based Care, Clinical Pathways, and Precision Medicine


J Clin Pathways. 2018;4(1):16-20.

Real-World Outcomes of Patients With NSCLC Treated With PD-1 Inhibitors After Approval

Certain subgroups of patients with NSCLC are underrepresented in clinical trials for newly approved PD-1 inhibitors and are needed to inform real-world treatment decisions.

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Immunotherapies Often Fail to Show Durable Survival in ASCO Value Framework

Results of a recent analysis showed that only 3 drug indications of 6 immuno-oncology agents met the durable survival threshold in the American Society of Clinical Oncology value framework.

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Most Cost-Effective Treatment Regimen Identified for Relapsed, Refractory Multiple Myeloma

A recent cost-effectiveness analysis evaluated treatments for relapsed or refractory multiple myeloma from a United States health system perspective.

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RA Biomarker Panel Identifies Older Patients at Risk of Cardiovascular Events

Higher scores on a multibiomarker disease activity system are associated with hospital infection, myocardial infarction, and coronary heart disease events in older patients with rheumatoid arthritis.

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Optimal First-Line Treatment for ALK-Positive Advanced NSCLC Identified

A recent study compared a targeted therapy with standard chemotherapy for treatment-naïve anaplastic lymphoma kinase-positive advanced non-small cell lung cancer.

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Intravenous Combination Regimen Safe, Effective in Older Patients With Type of Blood Malignancy

A potential new first-line therapeutic option may have been identified for older patients with a common blood cancer type.

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How Severe Are Immunotherapy Adverse Events for Cancer and Preexisting Autoimmune Disease?

A recent study summarized the available evidence on adverse events associated with checkpoint inhibitors in patients with cancer and preexisting autoimmune disease.

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Optimal Implementation Strategy for Blood Pressure Control Identified in Patients With Hypertension

A comparative effectiveness study analyzed various implementation strategies for BP control in patients with hypertension.

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VA Better Than Medicare in End-of-Life Care for Patients With Cancer

Patients with cancer treated through the Department of Veterans Affairs are less likely to receive excessive end-of-life interventions than patients treated through Medicare.

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